RESUMO
Antibodies to phospholipids (aPL) and associated proteins are a hallmark in the diagnosis of anti-phospholipid syndrome (APS). Those included in the classification criteria are the lupus anticoagulant (LA) and the IgG and IgM isotypes of anticardiolipin (aCL) and anti-beta-2 glycoprotein I (ß2GPI) antibodies. Non-classification criteria markers such as autoantibodies that recognize the phosphatidylserine/prothrombin (aPS/PT) complex have been proposed as biomarkers for APS. Studies of aPS/PT antibodies have shown a strong correlation to clinical manifestations and LA. We aimed to study the value and the persistence of aPS/PT IgG and IgM antibodies in a cohort of consecutive patients with clinical suspicion of APS and their utility as thrombotic risk markers. Our study, with 103 patients, demonstrates that persistently positive results for aPS/PT IgG antibodies were significantly associated with APS classification, thrombosis, triple aPL positivity, LA positive result, and the Global APS Score (GAPSS) > than 9 points (p < 0.01, for each condition). On the other hand, no association was seen with pregnancy morbidity (p = 0.56) and SLE (p = 0.07). Persistence of aPS/PT antibodies, defined according to the current laboratory classification criteria, likely improves the diagnosis and clinical assessment of patients with APS.
Assuntos
Anticorpos Anticardiolipina/sangue , Anticorpos Antifosfolipídeos/sangue , Síndrome Antifosfolipídica/imunologia , Autoantígenos/imunologia , Imunoglobulina G/sangue , Imunoglobulina M/sangue , Lúpus Eritematoso Sistêmico/imunologia , Fosfatidilserinas/imunologia , Protrombina/imunologia , Trombofilia/etiologia , beta 2-Glicoproteína I/imunologia , Adulto , Síndrome Antifosfolipídica/sangue , Doenças Autoimunes/sangue , Doenças Autoimunes/imunologia , Biomarcadores , Feminino , Humanos , Imunoglobulina G/imunologia , Imunoglobulina M/imunologia , Inibidor de Coagulação do Lúpus/sangue , Lúpus Eritematoso Sistêmico/sangue , Masculino , Pessoa de Meia-Idade , Gravidez , Complicações na Gravidez/sangue , Complicações na Gravidez/imunologia , Estudos Retrospectivos , Risco , Trombofilia/sangue , Fatores de TempoRESUMO
No disponible
Assuntos
Humanos , Autoimunidade/imunologia , Doenças do Sistema Imunitário/imunologia , Anticorpos Antinucleares/administração & dosagem , Antígenos Nucleares/imunologia , Algoritmos , Imunofluorescência/métodos , Programas de Rastreamento/métodos , Ensaio de Imunoadsorção Enzimática/métodosRESUMO
No disponible